Date of Award

12-16-2015

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Biology

First Advisor

Dr. Aaron Roseberry

Second Advisor

Dr. Kyle Frantz

Third Advisor

Dr. Laura Carruth

Abstract

Obesity has become a serious problem in the US. According to the Centers for Disease Control and Prevention, currently ~70% of the US population can be considered overweight or obese. In order to tackle the issue of obesity, it is very important to identify the neural mechanisms that regulate feeding. This will aid us to combat the bigger issue of obesity. The Arcuate nucleus contains two sets of neurons that play an important role in the control of feeding, while the mesolimbic dopamine system plays a major role in most reward based behavior including the reward-related responses to drugs and food. There have been increasing evidence of the melanocortin system interacting with the mesolimbic dopamine system in mediating hedonic feeding. In these studies we tested whether injecting the melanocortin receptor antagonist and agonist, SHU 9119 and MTII, in the ventral tegmental area (VTA) has an effect on reward-based food intake. MTII decreased reward based food intake while SHU9119 affected motivated food intake behavior at a high concentration. Overall, these studies increase our understanding the role of αMSH in the VTA on motivated food reward behavior.

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