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Dissertations from 2017

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Assessing Organic Chemistry Students’ Understanding Of Chemical Bonding Concepts and their Perception of a Project-based Lab, Nikita L. Burrows

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COMPUTATIONAL INVESTIGATIONS OF BIOMOLECULAR MOTIONS AND INTERACTIONS IN GENOMIC MAINTENANCE AND REGULATION, Bradley R. Kossmann

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Synthesis of Various Classes of Cyanine Fluorophores and Their Application In In Vivo Tissue Imaging, Andrew R. Levitz

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Comprehensive Glycoproteomics and Glycomics Study of N-Linked Glycans and N-Glycoproteins, Xu Li

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Applications of Monolithic Capillary Electrochromatography (CEC): Method Development and Quantitation of Metabolites in Prostate Tissue and Insights into Chiral Recognition Mechanism, Yang Lu

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Design Of Genetically-Encoded Ca2+ Probes With Rapid Kinetics For Subcellular Application, Florence Reddish

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Biochemical and Biophysical Studies of Heme Transport Proteins: HtaA, HtaB, and ChtB from the Corynebacterium diphtheriae, Rizvan C. Uluisik

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Facile Enzymatic Synthesis of Ketoses and Chemoenzymatic Reporter Strategy for Probing Complex Glycans, liuqing Wen

Dissertations from 2016

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Application of Human Glycosyltransferases in N-glycan Synthesis and Their Substrate Specificity Studies, Angie Dayan Calderon Molina

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Biochemical and Biophysical Studies of Heme Binding Proteins from the Corynebacterium diphtheriae and Streptococcus pyogenes Heme Uptake Pathways, Elizabeth B. Draganova

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Novel Anticancer Agents That Upregulate p53 and A New Type of Neighbouring Group Assisted Click Reactions, Alexander B. Draganov

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To Affinity & Beyond: Exploring Sequence Selectivity of Small Molecules for the DNA Minor Groove, Sarah Laughlin-Toth

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Chiral capillary electrophoresis-mass spectrometry: developments and applications of novel glucopyranosdie molecular micelles, yijin liu

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Transforming Dihydroxyacetone Phosphate-Dependent Aldolases Mediated Aldol Reactions From Flask Reaction Into Cell-Based Synthesis & Studying The Mechanism Of Chemical Desialylation In The Life Processes, Mohui Wei

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Chemical and Chemoenzymatic Synthesis of Outer Core Oligosaccharide of Escherichia Coli R3 and a Library of Human Milk Oligosaccharides & Design and Synthesis of Glycoconjugates, Zhongying Xiao

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Iron Catalyzed Selective Nitrogen Atom Transfer Reactions for Olefin Difunctionalization: Iron Catalyzed Direct Diazidation and Asymmetric Intramolecular Aminohydroxylation of Olefin, Yongan Yuan

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CALCIUM REGULATION OF CELL-CELL COMMUNICATION AND EXTRACELLULAR SIGNALING, Juan Zou

Dissertations from 2015

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Synthesis of Small Molecules for Diagnostics and Therapeutics of Influenza Virus, Hieu T. Dinh

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Calcium-Sensing Receptor Mediated Calcium Signaling in Cancer Bone Metastasis, Jie Feng

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Mass Transport through Conical Nanopipettes and its Applications in Energy Conversion and Crystallization, Yan Li

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I. Kinetic and Computational Modeling Studies of Dimethyldioxirane Epoxidations II. Adressing Misconceptions About Energy Changes in Chemical Reactions Through Hands-on Activities, Davita McTush-Camp

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Synthetically Tailored Cyanines for Imaging and Therapy, Eric Owens

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Kinetic and Structural Studies on Flavin-dependent Enzymes involved in Glycine Betaine Biosynthesis and Propionate 3-nitronate Detoxification, Francesca Salvi

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Biochemical and Mechanistic Studies of Nitronate Monooxygenase and Roles of Histidine Residues in Select Flavoprotein Oxidases, Crystal L. Smitherman

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Computational Perspective on Intricacies of Interactions, Enzyme Dynamics and Solvent Effects in the Catalytic Action of Cyclophilin A, Safieh Tork Ladani

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Quantification of Nonlinear And Dynamic Charge Transport Through Nanoscale Confinements, Dengchao Wang

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Studies on Boronic Acid-modified Nucleotides for Diagnostic Applications and Development of Fluorescent Chemoprobes for Molecules of Biological Importance, Ke Wang

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Development of Glycan Based Diagnostics to Detect Pathogens, xiaohu Zhang

Dissertations from 2014

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The Spectrochemical Characterization of Novel Vis-NIR Fluorescence Dyes and Developing a Laser Induced Fluorescence Capillary Zone Electrophoresis (LIF-CZE) Technique to Study Alkanesulfonate Monooxygenase, Garfield Beckford

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Mechanistic Enzymology of Flavin-dependent Catalysis in Bacterial D-Arginine Dehydrogenase and Choline Oxidase, Swathi Gannavaram

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Heme-dependent Tryptophan Oxidation: Mechanistic Studies on Tryptophan 2,3-Dioxygenase and MauG, Jiafeng Geng

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Synthesis of Aza-Heterocyclic Monoamidines as Potential DNA Minor Groove Binders, Anti-Trypanosomals, and Boron Neutron Capture Therapy Agents, Julius Green

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Detection and inhibition of influenza using synthetic sialosidesc, Yun He

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Structural and Mechanistic Studies on α-Amino β-Carboxymuconate ε-Semialdehyde Decarboxylase and α-Aminomuconate ε-Semialdehyde Dehydrogenase, Lu Huo

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Novel Selenium-modified Nucleic Acids For Structural and Functional Studies, Sibo Jiang

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Using Molecular Dynamics to Elucidate the Mechanism of Cyclophilin, Lauren McGowan

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Development of Novel Protein-Based MRI Contrast Agents for the Molecular Imaging of Cancer Biomarkers, Fan Pu

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Atom-Specific Modification of Uracil Bases with Selenium for RNA Structure and Function Studies, Huiyan Sun

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Molecular Dynamics Simulations Towards The Understanding of the Cis-Trans Isomerization of Proline As A Conformational Switch For The Regulation of Biological Processes, Hector Velazquez

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From "Click" to "Click and Release", Using Inverse Electron Demand Diels-Alder Reaction for Chemical and Medicinal Applications, Danzhu Wang

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One DNA minor groove, many possibilities: from sequence recognition to transcription factor inhibition, Shuo Wang

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Cleavage of Lipids and DNA by Metal Ions and Complexes, Dominique Williams

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“Coarse Grained" Bead Modeling of Macromolecules Transport in Free Solution and in a Gel, Hengfu Wu

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Modeling Assemblies and Interactions at the Replication Fork: Sliding Clamps and Clamp Interacting Enzymes, Xiaojun Xu

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Integration Of Extracellular And Intracellular Signals Via The Calcium Sensing Receptor (CASR), Chen Zhang

Dissertations from 2013

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Design and Synthesis of HIF-1 Inhibitors as Anti-cancer Therapeutics, Sarah Burroughs

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Inhibitors of SecA as Potential Antimicrobial Agents, Arpana S. Chaudhary

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The Structure and Function Study of Three Metalloenzymes That Utilize Three Histidines as Metal Ligands, Yan Chen

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Development of RNA Microchip for Pathogen and Cancer Direct Detection, Lilian W. Kamau-Gatogo

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Molecular Probe Designs For Nucleic Acid Based Detection, Manindar Kaur

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A Structural and Mechanistic Study of Two Members of Cupin Family Protein, Fange Liu

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DNA Interactions and Photocleavage by Anthracene, Acridine, and Carbocyanine-Based Chromophores, Carla Mapp

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Enzymatic Mechanisms and Chemical Probes of the Myst Family of Histone Acetyltransferases, Chao Yang

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Macromolecular Interactions in West Nile Virus RNA-TIAR Protein Complexes and of Membrane Associated Kv Channel Peptides, Jin Zhang

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Crystallographic Study of HIV Protease Drug Resistant Variants and Green Fluorescent Protein Based Calcium Sensor CatchER, Ying Zhang

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Modulating Calcium Signaling by Protein Design and Analysis of Calcium Binding Proteins, You Zhuo

Dissertations from 2012

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Characterization of the HEME Uptake Pathway Proteins from Streptococcus Pyogenes and Corynebacterium Diphtheriae, Neval -. Akbas

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Development of Antimicrobial Agent with Novel Mechanisms of Actions and 1,2,4,5-Tetrazine Click Chemistry and its Application in DNA Postsynthetic Functionalization, Weixuan Chen

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Dissecting Key Determinants for Calcium and Calmodulin Regulation of GAP Junction and Viral Protein, Yanyi Chen

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Kinetic Mechanism and Inhibitory Study of Protein Arginine Methyltransferase 1, You Feng

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Biophysical Characterization of the Binding of Homologous Anthraquinone Amides to DNA, Shirlene R. Jackson Beckford

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Calcium Modulates MGLUR1 Folding in ER in the Trafficking Process and Regulates the Drug Activity Upon the Receptor Expressing on the Cell Membrane, Yusheng Jiang

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Electrochemical Characterizations and Theoretical Simulations of Transport Behaviors at Nanoscale Geometries and Interfaces, Juan Liu

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Development of Bacterial Quorum Sensing Inhibitors and Molecular Probes, Hanjing Peng

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Biophysical Characterization of Synthetic Imidazole and Pyrrole Containing Analogues of Netropsin and Distamycin that Target Specific DNA Sequences for the Treatment of Various Diseases, Joseph P. Ramos

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Modulation and Recognition of Nucleic Acid Structures, Alexander M. Spring

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Rational Design and Application of Genetically Encoded Fluorescent Reporters in Cellular Physiology, Shen Tang

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Structure and Function Studies of Selenium Substituted Nucleic Acids, Wen Zhang

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Synthesis and Energetics of Gold Nanoclusters Tailored by Interfacial Bonding Structure, Tang Zhenghua

Dissertations from 2011

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I. Synthesis Of Anthraquinone Derivatives For Electron Transfer Studies In DNA. II. Characterization Of The Interaction Between Heme And Proteins., Yu Cao

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Development of Boronic Acid Flurescent Reporters, Boronic Acid-Modified Thymidine Triphosphates for Sensor Design and Antagonists of Bacterial Quorum Sensing in Vibrio Harveyi, Yunfeng Cheng

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Novel Near-Infrared Cyanine Dyes for Fluorescence Imaging in Biological Systems, Nilmi T. Fernando

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On the Biochemistry, Mechanism and Physiological Role of Fungal Nitronate Monooxygenase, Kevin Francis

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Chiral Analysis Using Capillary Electrophoresis Coupled to Mass Spectrometry: Development of Novel Modes and Applications Using Molecular Micelles and Surfactant-Bound Monolithic Columns, Jun He

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Tuning Calcium Bindging Affinities with Related Biological Functions of Calmodulin and Designing Protein Based Contrast Agent, Jie Jiang

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Nucleic Acid Substrates: Investigation of Structural and Dynamic Features that Influence Enzyme Activity, Christopher N. Johnson

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Defining a Molecular Mechanism for Lead Toxicity via Calcium-Binding Proteins, Michael Kirberger

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Targeted Molecular MR Imaging of HER2 and EGFR Using De Novo Designed Protein Contrast Agents, Jingjuan Qiao

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Protein-Nucleic Acid Interactions in Nuclease and Polymerases, abdur rob

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Development of Inhibitors and Assay Methods for Histone Acetyltransferases, Jiang Wu

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Mechanistic Studies of Two Selected Flavin-Dependent Enzymes: Choline Oxidase and D-Arginine Dehydrogenase, Hongling Yuan

Dissertations from 2010

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Synthesis of Fused Heterocyclic Diamidines for the Treatment of Human African Trypanosomiasis and Fluorescence Studies of Selected Diamidines, Jennifer Crystal Brown Barber

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Rational Drug Design for Neglected Diseases: Implementation of Computational Methods to Construct Predictive Devices and Examine Mechanisms, Catharine Jane Collar

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Roles of Serine 101, Histidine 310 and Valine 464 in the Reaction Catalyzed by Choline Oxidase from Arthrobacter Globiformis, Steffan Finnegan

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Design and Synthesis of Novel Serotonin Receptor Ligands, Jeffrey D. Klenc

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Design, Synthesis and Mechanistic Studies of Small Molecule Inhibitors of the Hypoxia Inducible Factor Pathway, Suazette Reid Mooring

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Sequence-Specific and Conformation-Specific Targeting of Duplex and Quadruplex DNA Grooves with Small Molecules, Rupesh K. Nanjunda

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Application of Boronic Acids in Medicinal Chemistry (Inhibitors, Sensors), Nanting Ni

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Bead Modeling of Transport Properties of Macromolecules in Free Solution and in a Gel, Hongxia Pei

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On the Catalytic Roles of HIS351, ASN510, and HIS466 in Choline Oxidase and the Kinetic Mechanism of Pyranose 2-Oxidase, Kunchala Rungsrisuriyachai

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Development of RNA Microchip for the Detection of Pathogens, Sarah M. Spencer

Dissertations from 2009

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Diagnosis and Inhibition Tools in Medicinal Chemistry, Senol Akay

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Synthesis and Enzymatic Studies of Selenium Derivatized Nucleosides, Nucleotides and Nucleic Acids, Julianne Marie Caton-Williams

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Metal-Assisted Hydrolysis of Biological Molecules, Sarah Shealy Cepeda

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Biochemical and Spectroscopic Characterization of Tryptophan Oxygenation: Tryptophan 2, 3-Dioxygenase and Maug, Rong Fu

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Development of Boronic Acid-Based Chemosensors, Shan Jin

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Detection and Quantification of Organophosphate Pesticides in Human Serum, Peter Kuklenyik

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On the Preorganization of the Active Site of Choline Oxidase for Hydride Transfer and Tunneling Mechanism, Osbourne Quaye

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NMR Study of Structure and Orientation of S4-S5 Linker Peptides from Shaw Related Potassium Ion Channels in Micelles and Binding of ZNF29R Protein to HIV RREIIBTR RNA, Xiaoguang Qu

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Synthesis, Structure and Function Studies of Selenium and Tellurium Derivatized Nucleic Acids, Jia Sheng