Date of Award
5-9-2016
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Chemistry
First Advisor
Dr. Hao Xu
Second Advisor
Dr. Alfons Baumstark
Third Advisor
Dr. Jun Yin
Fourth Advisor
Dr. Ivaylo Ivanov
Abstract
Numerous biologically active alkaloids and pharmaceuticals contain nitrogen atoms that are directly attached to stereogenic centers. Therefore, selective nitrogen atom transfer to readily available hydrocarbons through novel mechanistic pathways is an important tool for the synthesis of high-value functional molecules. We are interested in direct difunctionalization of alkenes with non-precious iron catalyst due to its advantages over well-established olefin aziridination and direct C-H amination methods in organic synthesis. Herein, we describe iron-catalyzed nitrogen atom transfer methods for stereoselective olefin difunctionalization, including olefin aminohydroxylation and diamination reactions. These transformations capitalize on the novel reactivity of iron catalysts by conveniently converting petrochemicals to highly functionalized building blocks that are valuable to organic synthesis, material and biomedical sciences.
DOI
https://doi.org/10.57709/8479242
Recommended Citation
Yuan, Yongan, "Iron Catalyzed Selective Nitrogen Atom Transfer Reactions for Olefin Difunctionalization: Iron Catalyzed Direct Diazidation and Asymmetric Intramolecular Aminohydroxylation of Olefin." Dissertation, Georgia State University, 2016.
doi: https://doi.org/10.57709/8479242