Inhibitors of SecA as Potential Antimicrobial Agents

Author

Arpana S. ChaudharyFollow

Date of Award

Summer 8-2-2013

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Chemistry

First Advisor

Binghe Wang

Second Advisor

Aimin Liu

Third Advisor

Suri Iyer

Abstract

Protein translocation is essential for bacterial survival and the most important translocation mechanism in bacteria is the secretion (Sec) pathway. Thus targeting Sec pathway is a promising strategy for developing novel antibacterial therapeutics.

We report the design, syntheses, mechanistic studies and structure-activity relationship studies using HQSAR and 3-D QSAR Topomer CoMFA analyses of 4-oxo-5-cyano thiouracil derivatives. In summary, introduction of polar group such as –N₃ and linker groups such as –CH₂-O- enhanced the potency as well as logP and logS several fold.

We also report the discovery, optimization and structure-activity relationship study of 1,2,4-triazole containing pyrimidines as novel, highly potent antimicrobial agents. A number of inhibitors have been found to inhibit microbial growth at high nanomolar concentrations.

DOI

https://doi.org/10.57709/4312613

Recommended Citation

Chaudhary, Arpana S., "Inhibitors of SecA as Potential Antimicrobial Agents." Dissertation, Georgia State University, 2013.
doi: https://doi.org/10.57709/4312613