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Theses from 2017

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Pirin Allosterically Modulates The Dynamics And Interactions Of The κB DNA In The NF-κB Supramolecular Complex, Charles Adeniran

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Insulin Nucleation Using Voltage Clamping and Current Clamping Techniques, Michael J. Bowen

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Synthesis Of Novel Organic Carbon Monoxide Prodrugs With Tunable Release For Biological Applications, Vayou Chittavong

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ANALYSIS OF DNA INTERACTIONS AND PHOTOCLEAVAGE BY PHENYL MESO SUBSTITUTED CYANINE DYES IN THE NEAR-INFRARED RANGE, Christina Fischer

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Synthesis & Evaluation Of Thiophene Derivatives As CXCR4 Antagonists, Francisco Javier Garcia Jr.

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Investigation and Characterization of Novel Pentamethine Cyanine Dyes for Use as Photosensitizers in Photodynamic Therapy, Kaitlyn Kiernan

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Atomistic Insights into Binding Pocket Dynamics and Regulation in the Interleukin-2 T-Cell Kinase SH2 Domain, Mohamed Momin

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DNA Encoded Libraries (DEGL) of Glycan Antigens to Detect Antibodies: An Approach Towards Next Generation Functional Glycomics, Aishwarya Parameswaran

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Computational Studies of Liver Receptor Homolog 1 in the Presence of Small Molecule Agonists: Allosteric Communication and Virtual Screening for New Potential Drug Candidates, Bernard Scott Jr

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Biophysical Heme Binding Studies of Corynebacterium diphtheriae and Streptococcus pyogenes, Stephanie Thompson

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Determination of Dynamical Conservation in Human Cyclophilin Isoforms, Phuoc Jake D. Vu

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Design and Synthesis of Inhibitors of Hypoxia Inducible Factor-1-mediated Functions, Lingyun Yang

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Chemoenzymatic Synthesis of UDP-GlcNAc and UDP-GalNAc Derivatives for Chemoenzymatic Labeling, Yuan Zheng

Theses from 2016

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SYNTHESIS OF 2SeU-RNAs AND RNA SQUARES, Xinghua Chen

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Synthesis and Determination of Optical Properties of Selected Pentamethine Carbocyanine Dyes, Tyler L. Dost

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DNA PHOTO-CLEAVAGE AND INTERACTIONS BY QUINOLINE CYANINE DYES; TOWARDS IMPROVING PHOTODYNAMIC CANCER THERAPY, Tayebeh Fatemipouya

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Optical Property Enhancement And Characterization Of Fluorescent Protein Based Intracellular Calcium Probes, Demesheka Goolsby

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Spectroscopic and Thermodynamic Characterization of Human 3-Hydroxyanthranilate-3,4-Dioxygenase, Calmour Henry

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Synthetic Development of Cyanine Dyes and Investigation of Their Interaction with Duplex DNA, Cory Holder

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Study Of The DNA Packaging Protein From A Phage That Replicates Under Extreme Conditions, Philip Lessans

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Exploring HIV Integrase 3’-processing Using Designed DNA Substrates and Structural Study of HIV DNA Hairpins, Qiushi Li

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Modifications To The Benzophenoxazine Architecture: Synthesis And Characterization, Vincent Martinez

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An Investigation of the DNA Interactions of Polyamine Anthracene Conjugates under High Ionic Conditions, Khoa Nguyen

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Establishing the Relationship Between Function and Dynamics Within the Gated Mechanism of D-arginine Dehydrogenase, Michael Souffrant

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Investigation Of A Novel Mammalian Thiol Dioxygenase Structure: Human Cysteamine Dioxygenase, Tseng Xiong and Tseng Xiong

Theses from 2015

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Discovery of Potent Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Using in silico Virtual Screening & Network Analysis for Evolution of Allosteric Communication in 3-ketosteroid Receptors, Shih-Wei Chuo

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A Novel Method for Bioanalysis of Dye Covalently Encapsulated in Silica Nanoparticles and Characterization of NIR Dyes for Future Approach, Kyle Emer

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Cyanine Dyes Targeting G-quadruplex DNA: Significance in Sequence and Conformation Selectivity, Hang T. Huynh

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Spectroscopic Studies of Cyanine Dyes and Serum Albumins for Bioanalytical Applications, Erica Lewis

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An Investigation of Autoxidation and DNA Thermal Cleavage by Polymethine Cyanine Dyes and Analogs in Aqueous Solutions, Ziyi Li

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synthesis of sulfated polysaccharides for colitis mice model, Qiang Ma

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Observation Of Spectral Changes To Trp-214 Residue In Human Serum Albumin Upon Binding With Mangiferin And Near Infrared Dyes, Jennifer Novak

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Mechanistic Investigation of the Flavin-Neighboring Residues S45, A46 and I335 in Pseudomonas aeruginosa D-arginine Dehydrogenase, Daniel Ouedraogo and Gioavanni Gadda

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Development of New Series of Protein Based MRI Contrast Agents: ProCA1 Variants and Humanized ProCA32, Anvi N. Patel

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Protein Modification of Designed MRI Contrast Agents, Corrie N. Purser

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Iron-Catalyzed Amino-Oxygenation and Aminofluorination of Olefins, Jeffrey Sears

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Synthesis and Characterization of New Near-Infrared Chromophores: Cyanine and Phenoxazine Derivatives, Eduardo Salvador Soriano Juarez

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G-quadruplex Polymorphism: a Winding Road from Structure to Therapeutics, Ekaterina M. Stroeva

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Spectroscopic Investigation into Minor Groove Binders Designed to Selectively Target DNA Sequences, Joseph Walton

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Glycosylation of Amino Acids and Efficient Synthesis of Glycosphingolipids, Jonathan Wooten

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Chemical Synthesis of Outer Core Oligosaccharide of Escherichia Coli R3 and Convergent Synthesis of O-glycan Library, Zaikuan Yu

Theses from 2014

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Optimizing the Production Parameters of Engineered Protein-Based MRI Contrast Agents, Rose Auguste

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Optimization of Thiolate Stabilized Gold Nanoclusters For Near Infrared Emission in Subcellular Imaging, Cecil Vincent Conroy

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Design and Synthesis of Small-molecule Inhibitors of the Hypoxia Inducible Factor-1 as Anticancer Therapeutics, Zeus Allen O. De Los Santos

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Synthesis Of Pyridyl Ethyl Amides As Potential Antitrypanosomal Agents, And Synthesis Of Arylimidamide-Azole Hybrids As Potential Antileishmanial Agents, Jennifer Draper

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Synthesis and Biochemical Studies of a Novel Thiol Modified Nucleotide, Razieh Esmaeili

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Targeting Holliday Junctions, Christopher Hamilton

Theses from 2013

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Discovery of Novel Cross-Talk between Protein Arginine Methyltransferase Isoforms and Design of Dimerization Inhibitors, Brandon S. Canup

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Synthesis of Novel Heterocyclic N-Oxide Glycosides: Glycosylation of Myxin Analogs, Jarin Joyner

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Unsymmetrical Trimethine Cyanine Dyes: Synthesis, Optical Properties, and Evaluations as Inhibitors of Protein Arginine Methyl Transferases, Andrew R. Levitz

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Probe Ca2+/Camodulin reguation of membrane proteins engineering, Xueyun Liu and Xueyun Liu

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Effects of Temperature on the Kinetic Isotope Effects for Proton and Hydride Transfers in the Active Site Variant of Choline Oxidase Ser101Ala, Rizvan C. Uluisik

Theses from 2012

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Nanoprecipitation in Quartz Nanopipettes and Application in the Crystallization of Inorganic Salts, Warren D. Brown

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Design and Synthesis of Thiamine Analogs as Anti-Cancer Therapeutics, Hieu T. Dinh

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Synthetic Development of the Tri- and Pentamethine Cyanine Chromophore for Biomolecular Interactions, Eric A. Owens

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Synthesis of Novel Fluorescent Benzothiazole Cyanine Dyes as Potential Imaging Agents, Shirish Paranjpe

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Studying the DNA Binding and Conformation of Metal-Binding Site Mutations in Pirin, Imran J. Rehmani

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Two-site DNA Minor Groove Binding Compounds, Shelby Diane Sheldon Deuser

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Synthesis of Coupling Substrates for Use in a Highly Enantioselective Conjugated Triene Cyclization Enabled by a Chiral N-Heterocyclic Carbene, Christopher A. Toth

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Synthesis of Chiral N-Heterocyclic Carbene Precursors and Key Intermediates for Catalytic Enantioselective Cyclizations of Conjugated Trienes, Phillip D. Wilkerson

Theses from 2011

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Spectroscopic Studies of Carbocyanine and 2,4,6- Trisubstituted Pyridine Dyes for Bioanalytical and pH Indicating Applications, Gala M. Chapman

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DNA Photocleavage by 9-Aminomethylanthracene Dyes at pH 7.0: Ionic Strength Effects, Blessing D. Deeyaa

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Interactions of Metals and Radicals: A Biochemical Perspective in Tryptophan Dioxygenase, Kednerlin Dornevil

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Novel Rhein Analogues as Potential Anicancer Agents and a Novel Metal Free Synthesis of 6H-ISOINDOLO[2,1-A]INDOL-6-ONE, Alexander B. Draganov

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Synthesis of Selective 5-HT7 Receptor Antagonists, Adam Ehalt

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Binding of Bisbenzamidines with AT Rich DNA: A Thermodynamic Study, Nancy A. Kilpatrick

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Arylboronic Acids With Strong Fluorescence Intensity Changes Upon Sugar Binding, Sarah R. Laughlin

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Cyanine Dye Interactions with Quadruplex and Duplex DNA: Changes in Conformation, Stability, and Affinity, Leah E. Mickelson

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Synthesis and Characterization of Metal Nanoclusters Stabilized by Dithiolates, Donald A. Robinson III

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Conformational Bias in 2'-Selenium-Modified Nucleosides and the Effect on Helical Structure and Extracellular Recombinant Protein Production: Current Systems and Applications, Richard A. Thompson

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Theoretical Modeling of Oligopeptides through Capillary Electrophoresis and Tarnsport Studies, Umar T. Twahir

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Optimization of Expression and Purification Methods for the Study of Protein-Based Magnetic Resonance Imaging Contrast Agents, Natalie White

Theses from 2010

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Synthesis of Substituted Pyrimidines and Pyridines as Ligands to the 5-HT7 Receptor, Ava L. Blake

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Synthesis of Near-Infrared Heptamethine Cyanine Dyes, Jamie Loretta Gragg

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Purification and Structural Characterization of a Novel Class of Protein- Based Magnetic Resonance Imaging Contrast Agents, Kendra Lynette Hubbard

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Determining Topological Effects of Heterocyclic Diamidines with AT Rich DNA: A Study Using Gel Electrophoresis, Mass Spectrometry, and the Polymerase Chain Reaction, Rebecca Ann Hunt

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An Analysis of Prominent Water Models by Molecular Dynamics Simulations, Quentin Ramon Johnson

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Development of a Novel DNA Microchip for Pathogen Detection, Khin Lay Maw

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Study of Cyanine Dye Binding to Amino Acids and Its Analytical Utility, Yonathan Merid

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Heterocyclic Cations as Potential Anticancer Agents: An Approach that Targets G-quadruplex with Different Binding Modes, Caterina Livia Musetti

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Synthesis of Selective 5-HT6 and 5-HT7 Receptor Antagonists, Elizabeth A. Raux

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Photocleavable Linker for Protein Affinity Labeling to Identify the Binding Target of KCN-1, Hang T. Tran

Theses from 2009

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Expression and Purification of Engineered Calcium Binding Proteins, Adriana P. Castiblanco

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SIAA and Neat2 Heme Binding Proteins from Streptococcus Pyogenes, Giselle M. Delgado

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Biochemical Study of Engineered Fluorescent Proteins as Calcium Sensors and the Effect of Calcium and PH in Cell Reproduction and Protein Expression, Malcom Arturo Delgado

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Site Directed Mutagenesis, Expression and Enzymatic Studies of the 60 kDa Human HIV-TAT 1 Interactive Protein, TIP60, Emilia N. Elangwe

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A Novel Method for the Quantitative Evaluation of Fibrinogen Coagulation, YIDAN LIU

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Structural Factors that Influence the Inhibition of Type II Restriction Enzymes by Minor Groove Binders, Ha Hoang Nguyen

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The Kinetics of Epoxidation of A,B-Unsaturated Esters by Dimethyldioxirane: A Mechanistic Study, John P. Sansone

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Heterocyclic Diamidines Induce Sequence Dependent Topological Changes in DNA; A Study Using Gel Electrophoresis, Denise Susanne Tevis

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Utility of Cationic and Anionic Chiral Surfactants in Capillary Electrophoresis (CE) and CE Coupled to Mass Spectrometry (CE-MS), Bin Wang

Theses from 2008

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Synthesis of 2,4-Disubstituted Pyrimidines of Possible Biological Interest, Samuel Barnes

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The Fate and Transport of Chemical Warfare Agent Simulants in Complex Matrices, Cedrick M., Daphney

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Cyclic Enzymatic Solid Phase Synthesis of DNA Oligonucleotides on an Epoxide-Activated Resin, Ahmed Mirza Khan

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Analyses and Applications of Metalloprotein Complexes, Michael Patrick Kirberger

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Biochemical Characterization of 2-Nitropropane Dioxygenase from Hansenula MRAKII, Slavica Mijatovic

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The Analysis of Antimicrobial Testing Vincetoxicum stocksii and Isolation of a Highly Active Compound Against Candida albicans by Using Various Different Techniques., Vasim Rasul Momin

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Electrochemical Studies of Substituted Anthraquinones, Daniel Joshua Rabinowitz

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Synthesis of 2,4-Disubstituted Pyrimidine Derivatives as Potential 5-HT7 Receptor Antagonist., Shannon M. Sullivan

Theses from 2007

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The Hydrolysis of Naphthalene Diimides, Michelle B. Kim