Date of Award
5-2-2008
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Dr. Lucjan Strekowski - Chair
Second Advisor
Dr. A.L. Baumstark
Third Advisor
Dr. Jerry Smith
Abstract
The synthesis of 2,4-disubstituted pyrimidine derivatives is described. The synthetic route involved the addition reaction of lithiated intermediates, mostly heterocycles, to position 4 of 2-chloropyrimidine to give a dihydropyrimidine intermediate which was oxidized back to a pyrimidine. This was followed by nucleophilic aromatic substitution with various amines of the chlorine in the position 2. A number of compounds were prepared which showed binding towards various serotonin receptors in preliminary biological evaluation.
DOI
https://doi.org/10.57709/1059231
Recommended Citation
Barnes, Samuel, "Synthesis of 2,4-Disubstituted Pyrimidines of Possible Biological Interest." Thesis, Georgia State University, 2008.
doi: https://doi.org/10.57709/1059231