Date of Award
Summer 8-12-2014
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Dr. Binghe Wang
Second Advisor
Dr. Kathryn B. Grant
Third Advisor
Dr. Maged M. Henary
Abstract
Throughout history, cancer has been severely plaguing mankind; the search for a
cure to cancer had long been sought by scientists and still poses as one of the
greatest challenges scientists have yet to overcome. Hypoxia in cells is a condition
where there is little to no oxygen availability in its environment. In general, this event
is detrimental since this can lead to cell necrosis or reoxygenation injuries. However,
hypoxia, a prominent property of most solid tumors, activates the hypoxia-inducible
factor (HIF-1) family of transcription factors that promotes angiogenesis. In this
study, we describe the design and synthesis of small-molecule inhibitors of the HIF-1
pathway.
DOI
https://doi.org/10.57709/5806967
Recommended Citation
De Los Santos, Zeus Allen O., "Design and Synthesis of Small-molecule Inhibitors of the Hypoxia Inducible Factor-1 as Anticancer Therapeutics." Thesis, Georgia State University, 2014.
doi: https://doi.org/10.57709/5806967