Date of Award

Summer 8-12-2014

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

Dr. Binghe Wang

Second Advisor

Dr. Kathryn B. Grant

Third Advisor

Dr. Maged M. Henary

Abstract

Throughout history, cancer has been severely plaguing mankind; the search for a

cure to cancer had long been sought by scientists and still poses as one of the

greatest challenges scientists have yet to overcome. Hypoxia in cells is a condition

where there is little to no oxygen availability in its environment. In general, this event

is detrimental since this can lead to cell necrosis or reoxygenation injuries. However,

hypoxia, a prominent property of most solid tumors, activates the hypoxia-inducible

factor (HIF-1) family of transcription factors that promotes angiogenesis. In this

study, we describe the design and synthesis of small-molecule inhibitors of the HIF-1

pathway.

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