Date of Award

Summer 8-8-2017

Degree Type

Capstone Project

Degree Name

Master of Public Health (MPH)

Department

Public Health

First Advisor

Ike Okosun Ph.D.

Second Advisor

Barbara Yankey Ph.D.

Abstract

Branched Chain Amino Acids (BCAA) have been associated with insulin resistance and type 2 diabetes. However, there is not concrete understanding on whether BCAA is playing a causal factor or a predictive factor for type 2 diabetes. The aim of this review is to understand how Branched Chain Amino Acids act as a predictive biomarker of type 2 diabetes (T2D) or causal factor in insulin resistance. Two mechanisms have been proposed, but not enough studies have been done to prove which is true. There is still a lot of unknowns in BCAA mechanisms and how it affects metabolic disorders. Future study recommendations have been made to further understand BCAA pertaining to T2D and other metabolic disorders. After reviewing current studies, there is not enough evidence to confirm whether BCAAs are causative or predictive of T2D.

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