Title

Donor-specific Cell-based Assays in Studying Sensitivity to Low-dose Radiation: A Population-based Perspective

Authors

Dora Il'yasova, Georgia State UniversityFollow
Alexander Kinev, Creative Scientist, Inc
C. David Melton
Faith G. Davis, University of AlbertaFollow

Document Type

Article

Publication Date

2014

Abstract

Currently, a linear no-threshold model is used to estimate health risks associated with exposure to low-dose radiation, a prevalent exposure in the general population, because the direct estimation from epidemiological studies suffers from uncertainty. This model has been criticized based on unique biology of low-dose radiation. Whether the departure from linearity is toward increased or decreased risk is intensely debated. We present an approach based on individual radiosensitivity testing and discuss how individual radiosensitivity can be assessed with the goal to develop a quantifiable measure of cellular response that can be conducted via high-throughput population testing.

Comments

Originally Posted in:

Front Public Health, 2 244. DOI: 10.3389/fpubh.2014.00244

Recommended Citation

D. Il'yasova, A. Kinev, C. D. Melton and F. G. Davis. 2014. Donor-specific cell-based assays in studying sensitivity to low-dose radiation: a population-based perspective Frontiers in Public Health, 2. doi: 10.3389/fpubh.2014.00244

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.