Date of Award
12-18-2012
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Mathematics and Statistics
First Advisor
Yi Jiang
Second Advisor
Xin Qi
Third Advisor
Yichuan Zhao
Abstract
Retinal pigment epithelium (RPE) is a principal site of pathogenesis in age-related macular de-generation (AMD). AMD is a main source of vision loss even blindness in the elderly and there is no effective treatment right now. Our aim is to describe the relationship between the morphology of RPE cells and the age and genotype of the eyes. We use principal component analysis (PCA) or functional principal component method (FPCA), support vector machine (SVM), and random forest (RF) methods to analyze the morphological data of RPE cells in mouse eyes to classify their age and genotype. Our analyses show that amongst all morphometric measures of RPE cells, cell shape measurements (eccentricity and solidity) are good for classification. But combination of cell shape and size (perimeter) provide best classification.
DOI
https://doi.org/10.57709/3487611
Recommended Citation
Yu, Jie, "Classification of Genotype and Age of Eyes Using RPE Cell Size and Shape." Thesis, Georgia State University, 2012.
doi: https://doi.org/10.57709/3487611