Date of Award
Doctor of Philosophy (PhD)
Andrew T. Gewirtz
Timothy L. Denning
Richard K. Plemper
Most viruses first encounter host cells at mucosal surfaces, which are typically colonized
by a complex ecosystem of microbes collectively referred to as the microbiota. Recent studies demonstrate the microbiota plays an important role in mediating host–viral interactions and determining the outcomes of these encounters. This thesis outlines the background and our findings of how bacteria and viruses impact each other, particularly during infectious processes. Mechanistically, these effects can be broadly categorized as reflecting direct bacterial–viral interactions and/or involving microbial impacts upon innate and/or adaptive immunity.
Shi, Zhenda; Zhang, Benyue; Zou, Jun; Zhang, Zhan; Dermody, Terence; Williams, Ifor; Kumar, Matam Vijay; Uchiyama, Robin; Noriega, Juan; Zhao, Chunyu; Bittinger, Kyle; Mattei, Lisa; Pruijssers, Andrea; Estes, Mary; Chassaing, Benoit; Denning, Timothy L.; Plemper, Richard K.; and Gewirtz, Andrew T., "INVESRIGATING BACTERIAL-VIRAL INTERACTIONS AND LEARN NOVEL MEANS TO COMBAT VIRAL INFECTIONS." Dissertation, Georgia State University, 2019.
Available for download on Wednesday, December 04, 2019