Date of Award

Spring 5-1-2019

Degree Type


Degree Name

Doctor of Philosophy (PhD)



First Advisor

Andrew T. Gewirtz

Second Advisor

Timothy L. Denning

Third Advisor

Richard K. Plemper


Most viruses first encounter host cells at mucosal surfaces, which are typically colonized

by a complex ecosystem of microbes collectively referred to as the microbiota. Recent studies demonstrate the microbiota plays an important role in mediating host–viral interactions and determining the outcomes of these encounters. This thesis outlines the background and our findings of how bacteria and viruses impact each other, particularly during infectious processes. Mechanistically, these effects can be broadly categorized as reflecting direct bacterial–viral interactions and/or involving microbial impacts upon innate and/or adaptive immunity.

Available for download on Wednesday, December 04, 2019