Date of Award

5-2-2018

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Biology

First Advisor

Walter Wathall

Second Advisor

Barbara Baumstark

Third Advisor

Chun Jiang

Abstract

C. elegans provides a number of tools for understanding cellular networks and neural connections. We identified jd1500 in previous reports as a mutation that affects forward locomotion, which is unusual. Our aims were to: 1) identify the gene responsible for the phenotype that jd1500 exhibits and 2) distinguish the basis for the locomotive asymmetries. Using next-gen whole genome sequencing, we were able to identify specific genes that are likely responsible for the phenotype it shows. Our results suggest that gap junction mutations mask jd1500 activity, but also suggest that jd1500 masks acr-2 activity.

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