Date of Award
Master of Science (MS)
C. elegans provides a number of tools for understanding cellular networks and neural connections. We identified jd1500 in previous reports as a mutation that affects forward locomotion, which is unusual. Our aims were to: 1) identify the gene responsible for the phenotype that jd1500 exhibits and 2) distinguish the basis for the locomotive asymmetries. Using next-gen whole genome sequencing, we were able to identify specific genes that are likely responsible for the phenotype it shows. Our results suggest that gap junction mutations mask jd1500 activity, but also suggest that jd1500 masks acr-2 activity.
Randall, Christian A., "Characterizing a Novel Forward Locomotion Mutant in Caenorhabditis Elegans." Thesis, Georgia State University, 2018.