Date of Award
8-7-2018
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Biology
First Advisor
Ritu Aneja
Second Advisor
Vincent Rehder
Third Advisor
Liana Artinian
Abstract
The ability of cancer cells to synthesize and store lipids in the form of lipid droplets (LDs) gives them a proliferative advantage over normal cells. Here, we elucidate the effect of monoethanolamine (Etn) on the lipid metabolism of LD-rich prostate carcinoma (PC3) cells. Etn is a ubiquitous molecule that serves as a phospholipid precursor and has been shown to have anticancer activity, although its mechanism of action is not fully understood. PC3 cells were treated with Etn and evaluated with a combination of biochemical and cell biology techniques. Treatment with Etn caused a decrease in cytosolic LD abundance induced by Ca2+-stimulated lipolysis. Our study effectively implicates the disruption of lipid metabolism as a contributor to Etn-induced cell death. This finding opens new avenues for the development of LD-targeted anticancer therapy.
DOI
https://doi.org/10.57709/12538625
Recommended Citation
McFaline-Figueroa, Jennifer, "Effect of Monoethanolamine on the Lipid Metabolism of Prostate Cancer Cells." Thesis, Georgia State University, 2018.
doi: https://doi.org/10.57709/12538625