Date of Award
Master of Science (MS)
Dr. Richard Dix
Sight threatening human cytomegalovirus (HCMV) retinitis still remains a cause for concern among AIDS patients who do not respond to or do not have access to current antiretroviral (ART) therapy . However, little is currently known about the degenerative mechanisms behind HHCMV retinal destruction during retroviral immunosuppression. The well-established murine AIDS (MAIDS) related murine cytomegalovirus (MCMV) retinitis model closely mimics disease progression seen in AIDS patients . Previous work using this model has shown that while the cell death pathway apoptosis is involved in disease progression, it is not fully responsible . It has been found that the mRNA of molecules associated with two other cell death pathways, necroptosis and pyroptosis, are also correlated with the pathophysiology of MAIDS-related MCMV retinitis . We propose that retinal degeneration seen during CMV retinitis involves necroptosis/pyroptosis programmed cell death correlating with the increased mRNA/protein expression of associated molecules observed in this study.
Duncan, Lauren-Asley, "Detection Of Necroptosis and Pyroptosis-Associated Molecules during Experimental MAIDS-Related Cytomegalovirus Retinitis." Thesis, Georgia State University, 2019.