Date of Award
5-10-2019
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Biology
First Advisor
Nancy Forger
Second Advisor
Aaron Roseberry
Third Advisor
Anne Murphy
Abstract
Naturally occurring perinatal cell death is a major developmental process in the formation of the brain. Microglia, the primary immunocompetent cells of the brain, have recently been implicated in actively contributing to perinatal cell death. However, the current research is contradictory. Some studies suggest that microglia induce neuronal death, while others suggest that microglia protect neurons from intrinsic cell death programs. These studies utilize many methods of manipulating microglia, they examine single regions of interest, and analyze at different times in development. These differences in analysis may be responsible for the different conclusions. In this study, we selectively reduced microglia brain wide via clodronate liposomes and measured the amount of microglial reduction and the subsequent effects on cell death. We also analyzed regional differences in cytokine expression as a possible underlying mechanism for effects of microglia on cell death.
DOI
https://doi.org/10.57709/14346786
Recommended Citation
Jacobs, Andrew, "Region-Specific Effects Of Microglial Depletion On Developmental Neuronal Cell Death In The Mouse Brain." Thesis, Georgia State University, 2019.
doi: https://doi.org/10.57709/14346786