Date of Award
Doctor of Philosophy (PhD)
Dr. Maged Henary
Dr. Suazette Mooring
Dr. Donald Hamelberg
A novel series of near-infrared fluorescent contrast agents was developed and characterized. Their physicochemical and optical properties were measured. By altering functional groups of cyanine fluorophores, the selective targeting of endocrine glands, exocrine glands, cartilage and bone using NIR fluorescence to visualize the targeted tissue has been reported. These agents have high specificity for tissue targeting inherent to the chemical structure of the fluorophore. After a single low-dose intravenous injection these agents have high specificity for tissue targeting inherent to the chemical structure of the fluorophore. The results lay the foundation for future improvements in optical imaging in endocrine surgery, tissue engineering, joint surgery, and cartilage-specific drug development.
Levitz, Andrew R., "Synthesis of Various Classes of Cyanine Fluorophores and Their Application In In Vivo Tissue Imaging." Dissertation, Georgia State University, 2017.
Available for download on Thursday, April 19, 2018