Synthesis of Various Classes of Cyanine Fluorophores and Their Application In In Vivo Tissue Imaging
Date of Award
5-10-2017
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Chemistry
First Advisor
Dr. Maged Henary
Second Advisor
Dr. Suazette Mooring
Third Advisor
Dr. Donald Hamelberg
Abstract
A novel series of near-infrared fluorescent contrast agents was developed and characterized. Their physicochemical and optical properties were measured. By altering functional groups of cyanine fluorophores, the selective targeting of endocrine glands, exocrine glands, cartilage and bone using NIR fluorescence to visualize the targeted tissue has been reported. These agents have high specificity for tissue targeting inherent to the chemical structure of the fluorophore. After a single low-dose intravenous injection these agents have high specificity for tissue targeting inherent to the chemical structure of the fluorophore. The results lay the foundation for future improvements in optical imaging in endocrine surgery, tissue engineering, joint surgery, and cartilage-specific drug development.
DOI
https://doi.org/10.57709/10044242
Recommended Citation
Levitz, Andrew R., "Synthesis of Various Classes of Cyanine Fluorophores and Their Application In In Vivo Tissue Imaging." Dissertation, Georgia State University, 2017.
doi: https://doi.org/10.57709/10044242