Date of Award
Master of Science (MS)
Dr. Binghe Wang
Dr. Donald Hamelberg
Dr. Suri S. Iyer
Hypoxia Inducible Factors (HIFs) are very important transcription factors that can respond to low oxygen concentrations in the cellular environment. Inhibition of HIF’s transcriptional activity represents a promising approach to new anticancer compounds. Herein, we describe the design and synthesis of a series of HIF-1 inhibitors. Evaluation of these inhibitors using a cell-based luciferase assay led to the discovery compounds with sub-micromolar potency.
Yang, Lingyun, "Design and Synthesis of Inhibitors of Hypoxia Inducible Factor-1-mediated Functions." Thesis, Georgia State University, 2017.
Available for download on Sunday, July 21, 2019