Date of Award
5-5-2008
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Lucjan Strekowski - Chair
Second Advisor
A.L. Baumstark
Third Advisor
Gabor Patonay
Fourth Advisor
Doyle Barrow
Abstract
The synthesis of a series of 2-chloropyrimidine derivatives is described. The synthesis began with a nucleophilic addition of lithiated heterocyclic molecules to the 4 position of 2-chloropyrimidine to give dihydropyrimidine intermediates. The intermediates were oxidized to the pyrimidine ring using the DDQ method. This was followed by an addition-elimination reaction of an amine to the 2-chloropyrimidine derivative. The structure and properties of the final compounds were analyzed by melting point, combustion analysis, and 13C-NMR and 1H-NMR spectroscopy. Biological activities in vitro of the synthesized compounds as antagonists of the 5-HT2a and 5-HT7 receptors were determined by an independent laboratory.
DOI
https://doi.org/10.57709/1059232
Recommended Citation
Sullivan, Shannon M., "Synthesis of 2,4-Disubstituted Pyrimidine Derivatives as Potential 5-HT7 Receptor Antagonist.." Thesis, Georgia State University, 2008.
doi: https://doi.org/10.57709/1059232