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Date of Award
Master of Science (MS)
Near-infrared (NIR) dyes have attracted attention in research and clinical applications due to their enhanced optical properties, pharmacokinetics, toxicokinetic, and feasible structure modifications. Current intensive research explores NIR hemicyanine dyes based on their improved sensitivity, stability, and photophysical properties as contrast agents and sensing probes. Herein we focus on designing, synthesizing, and analyzing hemicyanine dyes as fluorophores for photoacoustic imaging. By integrating various functional groups on their chemical scaffolds, the hemicyanine dyes can improve their photoacoustic signal and absorbance wavelength to advance their imaging properties. The absorption wavelengths of the synthesized hemicyanine dyes are within the range of 680 – 720 nm. In addition, our initial screening revealed that hemicyanine dyes modified with heavy atoms such as chlorine and bromine, rotatable bonds, hydrophobic moieties and charged groups provide better optoacoustic signals.
Tran, Tuyen, "Synthesis, and Characterization of Hemicyanine Dyes as Potential Contrast Agents for Photoacoustic Imaging." Thesis, Georgia State University, 2022.
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