Date of Award
8-11-2015
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Markus W. Germann
Second Advisor
W. David Wilson
Third Advisor
Maged Henary
Abstract
Structural and folding patterns of promoter regions (c-MYC, BCL) and telomeric (TTAGGG repeats) G-Quadruplexes were explored and their interactions with small molecules were tested. EAO-108 and MHI-21, symmetric heptamethine cyanines, were identified to exhibit strong interaction with the telomeric G-Quadruplex (mixed hybrid-1), while promoter region G-Quadruplexes were discriminated against. ZK-26 binds strongly to the c-MYC derivative and it is capable of discriminating between (3+1) hybrid-1 and -2 telomeric G-Quadruplexes with an initial binding preference towards the latter. To aid future binding studies, a novel labeling method is also described in this work.
DOI
https://doi.org/10.57709/7347411
Recommended Citation
Stroeva, Ekaterina M., "G-quadruplex Polymorphism: a Winding Road from Structure to Therapeutics." Thesis, Georgia State University, 2015.
doi: https://doi.org/10.57709/7347411