Spectroscopic Investigation into Minor Groove Binders Designed to Selectively Target DNA Sequences

Author

Joseph WaltonFollow

Date of Award

12-4-2015

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

W. David Wilson PhD

Abstract

Recently, there has been increasing focus toward the development of small molecules designed to target a specific sequences of double stranded DNA for therapeutic purposes¹. Minor groove binding compounds have been shown to be capable of selectivity target GC sites in AT tract DNA². In this research, binding selectivity was investigated using absorption, fluorescence and circular dichroic properties of selected DB minor groove binders in the presence of two unique DNA sequences. Further insight was gained by comparing the electrostatic potential maps and optimized structures of the compounds of interest. Using the results presented, potential selective minor groove binders can be selected for further investigation and kinetic studies.

DOI

https://doi.org/10.57709/7907374

Recommended Citation

Walton, Joseph, "Spectroscopic Investigation into Minor Groove Binders Designed to Selectively Target DNA Sequences." Thesis, Georgia State University, 2015.
doi: https://doi.org/10.57709/7907374