This study analyzes healthcare outcomes across the United States and focuses on regional disparities in health status, healthcare access, and service quality. It investigates the relationship between political leadership, socioeconomic factors, healthcare infrastructure, and overall health outcomes with emphasis on understanding the predictors of healthcare outcomes and the varying success rates within different states. The research is driven by concerns regarding inefficiencies within the U.S. healthcare system, which, despite advances in medical technology and specialized care, faces significant challenges in terms of unequal access and rising costs. Despite large expenditures, the U.S. exhibits poor health outcomes, such as high maternal mortality rates and persistent health disparities among low-income and minority populations. This study aims to identify the best and worst performing states in terms of broad health outcomes, measured with regard to the average number of days of physical and mental distress at the county level. By assessing socioeconomic factors such as income, education, and access to healthcare, the study seeks to understand their direct correlation with health results. Furthermore, the research considers the impact of rural versus urban healthcare access and investigates how regional disparities influence public health. The study hypothesizes that socio-economic factors affect healthcare outcomes. This research holds significant implications for policymakers, healthcare providers, and public health officials, offering insights into how targeted interventions can reduce health inequalities and optimize resource allocation. By focusing on the integration of socioeconomic factors with healthcare policies, the study found that factors like median household income, insufficient sleep and limited access to healthy food had significant impact on physical and mental distress.