This study investigates the relationship between sexual minority (LGBTQ+) discriminatory sentiment (SMDS) and Christian rhetoric in the United States that frame LGBTQ+ identities and sexual practices as immoral and condemned by God. In response to Christian rhetoric’s absorption into public discourse, this study draws on rhetorical theories of human engagement and pedagogy to argue that identification, empathy, listening, and education function, respectively, to mitigate discriminatory sentiment toward sexual minorities. This research adopts a transformative-worldview mixed methods design, appropriate for exploring social justice and oppression issues. Quantitative analysis, conducted via Momentive survey technology, explores the relationship between Christian rhetoric and discriminatory sentiment. These findings bolstered by qualitative discourse analysis of archived U.S. congressional records situate Christian rhetoric within the social and political context of lawmaking that denied LGBTQ+ couples marital rights. Additionally, qualitative discourse analysis of interview data assesses how rhetorical human engagement and education may prompt shifts in discriminatory beliefs. Results indicate (a) that Christian rhetoric (in its weaponized form) is correlated and situated in public policy that discriminates against sexual minorities, and (b) that rhetorical strategies rooted in human engagement and education can transcend ideological division and mitigate discriminatory sentiment. The study concludes by calling on religious rhetoricians to engage in sustained rhetorical inquiry that interrogates Christian rhetoric—aiming to alleviate discrimination against sexual minorities and advance principles of equity and social justice.