Latina mothers in the United States face a range of stressors that elevate their risk for developing depressive symptoms. However, research shows that cultural strengths, such as social support, can help offset the effects of risk factors like discrimination on overall mental well-being. This study examined the associations between discrimination, social support, and maternal depression among 271 Latina mothers living in the metro Atlanta area. Over the course of a four-year longitudinal study, participants completed measures assessing their experiences with perceived discrimination, social support, and depressive symptoms. To examine the relationship between these variables, we applied the Integrative Model of Developmental Competencies and Resilience Theory as frameworks to guide the interpretation of how risk and promotive factors influence maternal depressive symptoms over time. Latent growth curve modeling indicated that higher discrimination was associated with increased depression over time, whereas social support was associated with compensating for this effect, acting as a promotive factor. These findings were consistent with prior resilience-based literature that conceptualizes social support as a promotive resource for Latinas. Future research should continue to examine these dynamics to guide the development of culturally responsive, public health interventions aimed at reducing maternal depression among Latina mothers.