Ali Jalali, Baylor College of Medicine
E. Susan Amirian, Baylor College of MedicineFollow
Matthew N. Bainbridge, Baylor College of MedicineFollow
Georgina N. Armstrong, Baylor College of MedicineFollow
Yanhong Liu, Baylor College of MedicineFollow
Spyros Tsavachidis, Baylor College of Medicine
Shalini N. Jhangiani, Baylor College of MedicineFollow
Sharon E. Plon, Baylor College of MedicineFollow
Ching C. Lau, Baylor College of MedicineFollow
Elizabeth B. Claus, Yale UniversityFollow
Jill S. Barnholtz-Sloan, Case Western Reserve UniversityFollow
Dora Il'yasova, Georgia State UniversityFollow
Joellen Schildkraut, Duke UniversityFollow
Francis Ali-Osman, Duke University
Siegal Sadetzki, Tel-Aviv University
Christoffer Johansen, University of CopenhagenFollow
Richard S. Houlston, Institute of Cancer Research
Robert B. Jenkins, Mayo ClinicFollow
Daniel Lachance, Mayo ClinicFollow
Sara H. Olson, Memorial Sloan-Kettering Cancer centerFollow
Jonine L. Bernstein, Memorial Sloan-Kettering Cancer CenterFollow
Ryan T. Merrell, North Shore University Health SystemFollow
Margaret R. Wrensch, University of California, San FranciscoFollow
Faith G. Davis, University of AlbertaFollow
Rose Lai, University of Southern CaliforniaFollow
Sanjay Shete, The University of Texas MD Anderson Cancer CenterFollow
Kenneth Aldape, The University of Texas MD Anderson Cancer CenterFollow
Christopher I. Amos, Dartmouth CollegeFollow
Donna M. Muzny, Baylor College of MedicineFollow
Richard A. Gibbs, Baylor College of MedicineFollow
Beatrice S. Melin, Umea UniversityFollow
Melissa L. Bondy, Baylor College of MedicineFollow

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Glioma is a rare, but highly fatal, cancer that accounts for the majority of malignant primary brain tumors. Inherited predisposition to glioma has been consistently observed within non-syndromic families. Our previous studies, which involved non-parametric and parametric linkage analyses, both yielded significant linkage peaks on chromosome 17q. Here, we use data from next generation and Sanger sequencing to identify familial glioma candidate genes and variants on chromosome 17q for further investigation. We applied a filtering schema to narrow the original list of 4830 annotated variants down to 21 very rare (,0.1% frequency), non-synonymous variants. Our findings implicate the MYO19 and KIF18B genes and rare variants in SPAG9 and RUNDC1 as candidates worthy of further investigation. Burden testing and functional studies are planned.


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Sci Rep, 5 8278.doi:

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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