Infection control of Nosocomial spread of viral illnesses has long been a challenge for the safety of healthcare workers (HCWs) and their patients. The ongoing pandemic caused by the Sars-Cov-2 (COVID-19) virus has highlighted the importance of providing HCWs with the proper personal protective equipment (PPE). This study aims to explore differences between the PPE combination effect on reducing virus penetration at different levels virus concentrations with the use of a novel aerosol generation system. The PPE combinations used in the study: N95 respirator + face shield, surgical mask + face shield, surgical mask + N95, N95 respirator, face shield. The results of the study show that PPE can reduce virus exposures at a higher rate than when no PPE was used. The N95 respiratory was the most effective at reducing viral exposures. The results from the study may offer further insight into the best application of PPE within a medical setting.