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Synthesis of 2,4-Disubstituted Pyrimidines of Possible Biological Interest

Barnes, Samuel
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Abstract

The synthesis of 2,4-disubstituted pyrimidine derivatives is described. The synthetic route involved the addition reaction of lithiated intermediates, mostly heterocycles, to position 4 of 2-chloropyrimidine to give a dihydropyrimidine intermediate which was oxidized back to a pyrimidine. This was followed by nucleophilic aromatic substitution with various amines of the chlorine in the position 2. A number of compounds were prepared which showed binding towards various serotonin receptors in preliminary biological evaluation.

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2008-05-02
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2-chloropyrimidine, lithium, lithiated, heterocycle, heterocyclic, serotonin, pyrimidine, synthetic, synthesis, Organic, organic chemistry
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