Title: Optimizing Aerosol Therapy During Noninvasive Ventilation in Pediatric Patients: A Narrative Review Background: Noninvasive ventilation (NIV) is widely used in pediatric respiratory care, often in conjunction with aerosolized medications. However, the effectiveness of aerosol delivery in children remains uncertain due to anatomical, physiological, and behavioral complexities unique to this population. Objective: To systematically evaluate the influence of interface type, circuit configuration, and nebulizer placement on the effectiveness of aerosol therapy in pediatric patients receiving NIV. Methods: A comprehensive literature search was conducted in PubMed, Embase, and CINAHL using standardized indexing terms. A total of 328 records were screened, with 11 studies meeting inclusion criteria for qualitative synthesis. Studies were selected based on relevance to pediatric populations using NIV and reporting measurable clinical outcomes such as lung deposition, symptom improvement, adverse events, and hospital length of stay. Results: Oronasal masks were found to yield significantly higher pulmonary drug deposition (up to 30%) compared to nasal cannulas (1–6%). Dual-limb ventilator circuits outperformed single-limb setups in minimizing aerosol loss. Optimal nebulizer placement between the exhalation valve and patient was critical for maximizing drug delivery. Clinical outcomes associated with optimized aerosol therapy included reduced respiratory distress, shortened duration of respiratory support, lower intubation rates, and decreased hospital stays. Adverse events were rare but included skin and eye irritation when masks were poorly fitted. Conclusion: The effectiveness of aerosol therapy during pediatric NIV is closely linked to the selection of interface, ventilator circuit design, and nebulizer positioning. Evidence consistently supports the use of oronasal masks and dual-limb circuits, when tolerated by the patient, as these configurations maximize pulmonary drug deposition and clinical efficacy. Proper placement of the nebulizer, ideally between the exhalation valve and the patient, further enhances drug delivery. These adjustments not only improve therapeutic outcomes such as reduced respiratory distress and shorter hospital stays but also minimize the need for invasive ventilation and associated complications. Importantly, optimizing aerosol therapy in this context demands a patient-centered approach that balances drug delivery efficiency with comfort and tolerance. These findings offer a practical and evidence-based framework for clinicians seeking to refine aerosol administration strategies in pediatric NIV, ultimately contributing to safer, more effective, and personalized respiratory care. Keywords: Pediatric, NIV, aerosol delivery, nebulizer interface, lung deposition, respiratory therapy, noninvasive ventilation