Inherent in their living and working conditions, Migrant and Seasonal Farm Workers (MSFWs) are exposed to a multitude of environmental and psychosocial stressors that make them susceptible to adverse health outcomes. Utilizing a resilience framework, the current study examined both the physical and psychological health functioning of MSFWs in Georgia, a state heavily reliant on farm worker labor where relatively few research studies with MSFWs have been conducted to date. Based on a sample of 120 Latino, male, MSFWs in South Georgia, results indicated that approximately 1 out of 3 farm workers were at risk for iron-deficiency anemia. Similar to other psychological health studies conducted with MSFWs located in the Eastern U.S., the prevalence rate of depression in the current sample was elevated. MSFW stress was found to be a risk factor for psychological health and positive well-being and accurate farm worker expectations were found to be assets associated with better psychological health outcomes. Farm worker expectations was also found to be a protective factor for physical health such that having accurate expectations buffered the relationship between MSFW stress and adverse biomedical health. Results show the usefulness of the resilience framework, and highlight the importance of establishing prevention, intervention, and policy efforts for MSFWs that aim to increase assets and minimize risk in this population.