COPD is the third leading cause of death worldwide and is devastating to global health. By far, the leading cause of the development of COPD is the inhalation of combustible tobacco products. Current treatments are ineffective and have many side effects. The following review of the literature aims to explain the complex pathophysiology of COPD, detail the roles of inflammation and oxidative stress induced by noxious particles, and suggest a potential role of the vitamin E isoforms, tocotrienols specifically, as a complementary therapy.