Introduction: Homelessness is a living condition associated with a number of adverse health outcomes. Unaccompanied homeless youth are at risk for many of the same health outcomes as other homeless persons, but these youth are especially vulnerable because they are young and without the protection or support of an adult caregiver. Aim: The purpose of this capstone project is to present a basic overview of the topic as well as to highlight what more needs to be done to address this issue. Methods: This project involved a review of the literature related to homeless youth, child sexual or physical abuse, and mental health issues associated abused and/or homeless youth, focusing on United States information, for the years 1995 to present. Discussion: to discuss current prevention and intervention efforts, and to discuss needs for future research and intervention