Over the last few decades, the rapid expansion of the Atlanta urban area has led to the increase of the number of sources of pollutions around the area and the level of pollution in the Chattahoochee River. This research analyzed the change in the distribution of sources of contamination over time and space, and evaluated their impact on environmental justice in the Atlanta metropolitan area. The results indicate contaminated areas increased from 2000 to 2019, spreading from the central metropolitan area to the south along the Chattahoochee River. The Box and whisker plots indicated existence of spatio-temporal variations in the water quality parameters, with Ca, Mg, Fe, SiO2, NO3, and Cl displaying a relatively large length of boxes and whiskers compared to other parameters. The results show a disproportionate exposure to environmental hazards regarding income, race, age, and sex, and no application of environmental justice principles to the study area.