The objective of this study is to compare suicidal thoughts amongst American Indian/Alaskan Native's (AI/AN) to a non-AI/AN comparison group, using data from the National Longitudinal Study of Adolescent Health, a nationally-representative, longitudinal study. At wave one a statistical difference is present between NA/AN and comparisons, but at wave four the difference is no longer significant. Using Agnew’s General Strain theory as a theoretical framework, factors that may contribute to these differences addressed in this study include: alcohol abuse, exposure to suicidal behavior of friends and family, depression, and weapon access. Implications for prevention and treatment are discussed.