This Playbook is produced by The Atlanta Regional Collaborative for Health Improvement (ARCHI) for use by anyone who would like to align with ARCHI’s vision and contribute to collective impact. It describes the circumstances that gave rise to this new collaborative and why we expect success in creating substantial, sustainable improvements for Atlanta. The Playbook presents the elements of ARCHI members’ shared agenda and the roles these elements play in the health, health care, and economy of Atlanta. It provides guidance on using evidence in choosing and prioritizing interventions and lists specific, evidence-informed interventions for consideration. These lists are not exhaustive, and Playbook users are encouraged to consider other interventions that have evidence for effectiveness as well. The lists do provide a broad menu of well-vetted strategies and are a good place to start. They were developed by ARCHI subcommittees, who also identified which might yield “quick wins” and offered some local examples of existing efforts.