Depression is a common but serious illness, which may have significant impact on a person’s daily life. This study examined racial/ethnic disparities on the prevalence of lifetime diagnosis of depression and current depression according to 2010 Behavioral Risk Factor Surveillance System (BRFSS) data. Logistic regression models were constructed to calculate odds ratios for comparing prevalence rates of depression across racial/ethnic groups. Significant racial/ethnic differences were found in both the prevalence of lifetime diagnosis of depression and current depression. Regional disparities were also found to be significant in the prevalence of depressive disorders across racial/ethnic groups.