Throughout history, cancer has been severely plaguing mankind; the search for a A cure for cancer has long been sought by scientists and still poses as one of the greatest challenges scientists have yet to overcome. Hypoxia in cells is a condition where there is little to no oxygen availability in its environment. In general, this event is detrimental since it can lead to cell necrosis or reoxygenation injuries. However, hypoxia, a prominent property of most solid tumors, activates the hypoxia-inducible factor (HIF-1) family of transcription factors that promotes angiogenesis. In this In this study, we describe the design and synthesis of small-molecule inhibitors of the HIF-1 pathway.