BACKGROUND: Job satisfaction has been a significant issue for healthcare organizations in recent years due to job satisfaction’s influence on performance and the quality of patient care. Although job satisfaction has a strong association with respiratory therapists' performance, the job satisfaction of Saudi Arabian respiratory therapists (RTs) has not previously been examined. PURPOSE: This cross-sectional study aimed to measure the job satisfaction level among Saudi Arabian RTs. This study aimed to identify the occupational and personal characteristic factors that influence job satisfaction. The study also investigated the educational background's influence on job satisfaction. METHODS: The study used a cross-sectional survey that consist of two sections: the sociodemographic section and the Job Satisfaction Survey (JSS), which was developed by Paul Spector in 1985. RESULTS: A total of 140 responders participated and completed the research survey. The research found that payment, promotion, fringe benefits, and contingents rewards were associated with dissatisfaction among RTs. In contrast, the nature of work and coworkers were found to be associated with improving job satisfaction in Saudi Arabian RTs. The study findings found no significant association between personal factors and overall job satisfaction. In addition, the study found that RTs who work for 8 hrs were found to be more satisfied with their job compared to RTs who work for 12 hrs. The study found that RTs who studied in the US were more satisfied with their nature of work compared to RTs that studied in Saudi Arabia. CONCLUSIONS: RTs were not satisfied with their payment, promotion, fringe benefits, and contingent rewards, while they were satisfied with coworkers' relationships and nature of work. Further study is needed to understand job satisfaction among Saudi Arabian RTs and factors that could influence job satisfaction since these studies will increase healthcare organizations' and respiratory care departments' awareness about the job satisfaction of their RT employees.