Medical-Legal Partnerships (MLPs) have emerged as an innovative model for addressing adverse social determinants of health (SDOH) through interdisciplinary collaboration between healthcare and legal professionals. This dissertation employs a three-pronged approach to assess the impact of MLPs on SDOH through the Social Ecological Model (SEM), as well as their impact on interprofessional education and healthcare utilization outcomes. First, a systematic review examines how current MLP research aligns with the SEM, identifying gaps and opportunities for program development and evaluation. The findings reveal that while MLPs conceptually address SDOH at multiple levels, there is a scarcity of empirical research quantifying their outcomes within the constructs of the SEM framework. Second, the dissertation evaluates the effectiveness of interdisciplinary education and training (IDET) within MLPs in fostering interprofessional collaboration (IPC) among emerging healthcare professionals. Using survey data from fourth-year medical students, the study assesses shifts in knowledge, attitudes, and referral practices following participation in MLP-directed IDET. The results suggest that while students enter with a strong understanding of SDOH, experiential learning enhances their professional skills and inclination to refer patients to legal services when experiencing health harming legal needs. Third, a retrospective observational study assesses the impact of MLP services on healthcare utilization and costs. By analyzing administrative claims data, the study explores the relationship between legal services and emergency department, inpatient, clinic, outpatient, other visits and inpatient days and associated healthcare expenditures. While findings indicate a trend toward improved healthcare access and utilization, statistical significance remains limited, highlighting the complexity of measuring MLP effectiveness. This research underscores the potential of MLPs to mitigate adverse SDOH through direct services, education, and systemic advocacy. It also highlights the need for more rigorous, empirically driven studies to measure MLP impact across the SEM. Future research should incorporate matched comparison groups, longitudinal analyses, and enhanced data integration to better quantify the role of MLPs in improving health outcomes and reducing healthcare disparities.