Nucleic acids are complex macromolecules that can store and transfer information for generations; they are an integral part of the central dogma of molecular biology. Structural determination of nucleic acids is crucial to learn about their characteristics and functions. However, there are two problems in determining the structure of a nucleic acid: the phasing problem and the crystallization problem. Selenium modification of nucleic acids is an ideal way to counter both issues. This thesis paper focuses on the synthesis of 2’-SeMe-arabino modification of uridine and cytidine as they both may enhance the crystallization capabilities of B-form DNA. Advances in these studies may lead to the discovery of new drugs and therapeutics designed to target diseases with minimum dosage and highest precision possible.