Response cards (RC) support effective teaching strategies such as maintaining a brisk pace of instruction, increased opportunities to respond, immediate and frequent corrective feedback, and high rates of behavior specific praise statements; all of which have been effective in increasing student engagement for students with and without emotional and behavioral disorders (E/BD) (Emmer & Stough, 2001; Simonsen et al., 2008; Sutherland, Wehby, & Copeland, 2000). RC during academic instruction are successful in decreasing disruptive behavior, increasing student participation, and increasing academic achievement from the elementary school level to the university level. This study examined teacher implementation of RC at the high school level for students without disabilities and students with disabilities with a history of challenging behaviors (i.e., students with a disability and a behavior intervention plan) in general education classes required for high school graduation. The purpose of this study was to evaluate the effect of RC compared to hand raising (HR) in inclusive general education classrooms. An alternating treatment design was implemented to examine the potential functional relation between the use of RC, student engagement, and academic achievement. RC (i.e., 8” x 11” laminated write-on cards) were randomly alternated with the more traditional method of HR which allows one student to respond to each question asked by the teacher. Intervals of time on-task, attempted responses, next day quiz scores, and bi-weekly probe scores were measured and analyzed for target students without disabilities and target students with disabilities. In addition, individual scores of all students in the class were calculated to provide a class mean, allowing further analysis. All sessions were conducted by classroom teachers during daily reviews of academic content. The findings from this study support prior research indicating RC increases student engagement by increasing intervals of time on-task and attempted responses for the majority of students. In one class, three of four target students increased daily quiz scores by 10% or more using RC; and in the second class the mean for daily quiz scores was higher using RC. Although results on next-day quizzes were inconsistent, bi-weekly probes indicate RC increased >retention of material learned over time.