Antivirus software is a program designed to keep computer devices clean from malicious software (malware) such as viruses, worms, and trojans, and is commonly deployed on computer and smartphone users’ devices as the last line of defense against cyber-dependent crimes). In effort to assess the potential effectiveness of Antivirus products in preventing the development and progression of cyber-dependent crimes we searched in six major academic search engines for studies published between the years 2000-2016 using experimental or quasi-experimental research designs. Our findings reveal that several key approaches are employed by scholars when evaluating antivirus software’s performance.