This paper explores how changing conceptions of religion, race, and gender at the beginning of the twentieth century promoted transnational anti-systemic movements and increased cooperation between progressive intellectuals and political activists. Using the cases of Bertrand Russell, George Bernard Shaw, W.E.B. Du Bois, Marcus Garvey, Jane Addams, and Sylvia Pankhurst, this paper chronicles and analyzes protest to the First World War and objection to the organization of the world-system.