Migrant and Seasonal Farm Workers (MSFWs) in the United States live and work within ever changing contexts, which require researchers to take into account multiple environmental and psychosocial stressors influencing mental health. The current study examined factors of social support and social isolation for MSFWs in South Georgia. Social isolation and support characteristics were identified and examined in association with depression among 120 Latino, male, MSFWs in South Georgia. Several protective and risk factors for depression were identified. Depression symptoms varied based on MSFWs household composition, perceived social isolation stressors, the frequency in which they called home and having socially supportive relationships in the local area. Results highlight the importance of examining social support in the context of cultural and community fit.