Maintaining a clinical HIV/AIDS section in an academic library collection that is both current and historically significant for research is essential. This article reports on a collection management project that was undertaken to weed HIV/AIDS books in targeted clinical areas of an academic library using a timeline model developed by Ondrusek (2001) as a supplement to traditional weeding methods. The combination proved effective for identifying clinical materials that were outdated and needed to be deaccessioned while maintaining historically relevant materials in these areas.