Despite recent interest in the role of trust in Information Systems, the potential of IS to foster trust in business relationships remains largely untapped. In order to better realize this potential, this dissertation examines three areas of IS trust research for which research is particularly limited: (1) the IT artifact as a target of trust, (2) IS-based source credibility as an antecedent of trust, and (3) the effect of anonymity on trust in online environments. The objective of this dissertation is to examine the effects of IS on trust in each of these areas. To do so, a multi-paper dissertation format is adopted in which each area examined constitutes a distinct, though complimentary, study. Together, these studies further research on how IS can enhance trust in business relationships.