Post-stroke depression (PSD) affects at least one out of every three stroke survivors worldwide and presents with a variety of symptoms. The likelihood of its development relates to individual biological, psychological, and social circumstances, yet incidences are rarely addressed in the literature. Moreover, the presence of aphasia in some cases makes identifying PSD challenging. The purpose of this study was to investigate the incidence of PSD in adults with aphasia compared the incidence of PSD in adults without aphasia in an acute care setting, and to identify risk factors for PSD in adults with aphasia. Results indicated that adults with aphasia are 7.408 times more likely to exhibit PSD than adults without aphasia. Logistic regression controlling for the presence of aphasia showed a significant relationship between aphasia severity and PSD. Adults with aphasia were 2.06 times more likely to experience PSD with every 1-point increase in aphasia severity.