Modeling and simulation provides a powerful technology for engineers and managers to understand, design, and evaluate a system under development. Traditionally, simulation is only used in early stages of a system design. However, with the advances of hardware and software technology, it is now possible to extend simulation to late stages for supporting a full life cycle simulation-based development. Robot-in-the-loop simulation, where real robots work together with virtual ones, has been developed to support such a development process to bridge the gap between simulation and reality.