Date of Award
Summer 8-1-2011
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Mathematics and Statistics
First Advisor
Dr. Tzesan Lee
Second Advisor
Dr. Gengsheng (Jeff) Qin
Abstract
One of the issues regarding the misclassification in case-control studies is whether the misclassification error rates are the same for both cases and controls. Currently, a common practice is to assume that the rates are the same (“non-differential” assumption). However, it is suspicious that this assumption is valid in many case-control studies. Unfortunately, no test is available so far to test the validity of the assumption of non-differential misclassification when the validation data are not available. We propose the first such method to test the validity of non-differential assumption in a case-control study with 2 × 2 contingency table. First, the Exposure Operating Characteristic curve is defined. Next, two non-parametric methods are applied to test the assumption of non-differential misclassification. Three examples from practical applications are used to illustrate the methods and a comparison is made.
DOI
https://doi.org/10.57709/2091883
Recommended Citation
Hui, Qin, "Testing an Assumption of Non-Differential Misclassification in Case-Control Studies." Thesis, Georgia State University, 2011.
doi: https://doi.org/10.57709/2091883