Date of Award
Fall 12-11-2012
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Mathematics and Statistics
First Advisor
Dr. Yi Jiang
Second Advisor
Dr. Xin Qi
Third Advisor
Dr. Yichuan Zhao
Abstract
Aged-related macular degeneration (AMD) is a common eye condition among people older than 65 years and is a leading cause of vision loss. It gradually destroys the macula, the part of the eye that provides sharp, central vision needed for seeing objects clearly. This study aims to test the hypothesis that the morphology of retina pigment epithelium, a key site of AMD pathology, can reflect the various stresses aging and AMD progression impose. We first identify and separate the young and old age group for mouse eyes. Then we classify, the mouse eyes using two genotypes (C57BL/6L, RD10), and two age group (young, old).We show that without dimensional reduction, the cell area and shape measures do not provide good classification of the mouse eyes.
But with the dimension reduction at the eye level, the cell area and shape measures provide excellent classification for mouse genotype and age.
DOI
https://doi.org/10.57709/3218358
Recommended Citation
Folarinde, Micheal Shola, "A Comparative Study Between Genotypes and Ages of Eyes Using Morphometric Measures of Retinal Pigment Epithelial Cells." Thesis, Georgia State University, 2012.
doi: https://doi.org/10.57709/3218358