Date of Award
5-3-2007
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Mathematics and Statistics
First Advisor
Dr. Yu-Sheng Hsu - Chair
Abstract
In non-inferiority trials, the goal is to show how an experimental treatment is statistically and clinically not inferior to the active control. The three-arm clinical trial usually recommended for non-inferiority trials by the FDA. The three-arm trial consists of a placebo, reference, and an experimental treatment. The three-arm trial shows the superiority of the reference over the placebo and comparison of the reference to an experimental treatment. In this paper, I will assess a non-inferiority trial with Bayesian methods. By employing Bayesian analysis, the parameters are random and assign vague prior distributions. I will compare the models involving different prior distributions to assess the best fit model.
DOI
https://doi.org/10.57709/1059683
Recommended Citation
Britton, Marcus Chenier, "Bayesian Approach to Three-Arm Non Inferiority Trials." Thesis, Georgia State University, 2007.
doi: https://doi.org/10.57709/1059683